The Orange Haired Girl of Jimmy Corrigan

Throughout the last half of Jimmy Corrigan, the orange haired girl has a dominating role in the flashbacks. It seems as if Jimmy has feelings toward her; first feeling "love" and later hatred and jealousy. But, in their first meeting the orange haired girl confesses to Jimmy that she is actually a boy. This does not seem to make any difference in later conversations/actions between the two characters, so would this be important? Is she even a boy?